Buses to/from Bangkok's Northern (Mo Chit) Bus Terminal depart every 15 minutes from early until late.For quicker service, avoid the touts at Mo Chit, and ask for Chan Tour.Needless to say that there are countless of young and attractive local Thai girls to be met.
There are various night markets, which also are good places to try out many different kinds of foods; a "young and hip" market at Khon Kaen University behind the Complex where students sell many of the goods, a popular one on Glang Muang Rd, and one that sometimes doubles as a carnival, at Bueng Kaen Nakhon.
Along the road from the Roma Hotel (same side of the road), there are several cheap street eateries. A 7-Eleven (alcohol sales - and -) is nearby where you can buy beer if you want to drink with your meal, use the shop's bottle opener. The "big" terminal, where most buses arrive and leave and the "small" terminal, which is somewhat more exclusive and appears to provide the "direct to BKK" type of buses. They are about 1 km distant from each other within the centre of town, unlike most Thai cities where the bus terminals are on the outskirts.
Really by walking around town during daytime and almost getting bored if you don’t know the nice places to visit you wouldn’t think that this place has so much to offer after sunset.
Khon Kaen is the second biggest town in Isaan (after Korat) and has the biggest and oldest university in all of northeastern Thailand.
They are slightly faster than the bus, but probably not as comfortable. Hwy 2 also heads north to Udon Thani, Nong Khai, and Laos.